Synthesis and Radiation Dosimetry of [<sup>68</sup>Ga]-Ga-Lys<sup>1</sup>, Lys<sup>3</sup>-DOTA-Bombesin (1,14) Antagonist for PET-Imaging, as a Potential Theragnostic Tracer in Oncology

• 作者: Cristian Cabezas-Ortiz Géiser Rodríguez-Mena Juan C. Manrique-Arias Osvaldo García-Pérez Quetzali Pitalua-Cortes Roberto Pedrero-Piedras Tessy López
• 来源期刊: 封装与吸附期刊(英文)
• 学科: 医学
• 关键词: Radiation Dosimetry Biodistribution PET Imaging RADIOPHARMACEUTICAL Lys¹ Lys³-DOTA-BBN (1 14) Bombesin Analogs
• 年，卷（期）: 2020,（2）
• 页码范围: 29-41
• 页数: 13页
• 分类号: R73

摘要

This Bombesin (BBN), a tetradecapeptide analog of human gastrin-releasing peptide (GRP) with a high binding affinity for GRP receptors (GRPR), is over- expressed in early stages of androgen-dependent prostate carcinomas, but not in advanced stages. Therefore, there is a need to develop effective tracers for the accurate and specific detection of this disease. The objective of this study was to evaluate Lys¹, Lys³-DOTA-BBN (1,14) analog with the radiolabeled positron emitter [⁶⁸Ga]-Ga-BBN for receptor imaging with PET, and to determine its biodistribution and radiation dosimetry using whole-body (WB) PET scans in healthy volunteers. The highest uptake was in the pancreas, followed by urinary bladder. The critical organ was pancreas with a mean absorbed dose of 206 ± 0.7, 210 ± 0.7, 120 ± 0.9, 390.23 ± 0.6 μGy/MBq and the effective doses were estimated as 73.2 ± 0.6, 49.8 ± 0.3 μGy/MBq (women and men, respectively).