Associations of soybean products intake with blood pressure changes and hypertension incidence: the China-PAR project

• 作者: Chong SHEN Dong-Sheng HU Fang-Chao LIU Fang-Hong LU Ji-Chun CHEN Jia-Liu WEI Jian-Feng HUANG Jian-Xin LI Jie CAO Xiang-Feng LU Xin-Yan WANG Ying-Xin ZHAO
• 来源期刊: 老年心脏病学杂志（英文版）
• 年，卷（期）: 2020,（7）
• 所属期刊栏目: RESEARCH ARTICLE
• 页码范围: 384-392
• 页数: 9页
• 语种: 英文
• DOI: 10.11909/j.issn.1671-5411.2020.07.005

摘要

Background The relationships between dietary intake of soybean products and incident hypertension were still uncertain.This study aimed to illustrate the associations between intake of soybean products with risks of incident hypertension and longitudinal changes of blood pressure in a prospective cohort study.Methods We included 67,499 general Chinese adults from the Project of Prediction for Atherosclerosis Cardiovascular Disease Risk in China (China-PAR).Information about soybean products consumption was collected by standardized questionnaires,and study participants were categorized into the ideal (≥ 125 g/day) or non-ideal (＜ 125 g/day) group.Hazard ratios (HRs) and corresponding 95％ confidence intervals (95％ CIs) for incident hypertension were calculated using Cox proportional hazard models.Among participants with repeated measures of blood pressure,generalized linear models were used to examine the relationships between soybean products consumption and blood pressure changes.Results During a median follow-up of 7.4 years,compared with participants who consumed ＜ 125 g of soybean products per day,multivariable adjusted HR for those in the ideal group was 0.73 (0.67-0.80).This inverse association remained robust across most subgroups while significant interactions were tested between soybean products intake and age,sex,urbanization and geographic region (P values for interaction ＜ 0.05).The mean systolic and diastolic blood pressure levels were 1.05 (0.71-1.39) mmHg and 0.44 (0.22-0.66) mmHg lower among participants in the ideal group than those in the non-ideal group.Conclusions Our study showed that intake of soybean products might reduce the long-term blood pressure levels and hypertension incidence among Chinese population,which has important public health implications for primary prevention of hypertension.