Contribution of neutrophils in the pathogenesis of rheumatoid arthritis

• 来源期刊: 生物医学研究杂志（英文版）
• 学科: 医学
• 年，卷（期）: 2020,（2）
• 页码范围: 86-93
• 页数: 8页
• 分类号: R593.22
• 语种: 英文

摘要

Neutrophils are major innate immune effector cells for host defense and have been a topic of active research for their participation in the pathogenesis of autoimmune inflammatory diseases including rheumatoid arthritis (RA)due to recently discovered neutrophil extracellular trap (NET) formation.NET formation and other mechanisms leading to the release of neutrophil nuclear and cytoplasmic contents are implicated as a source of citrullinated antigens in RA.Further investigations are required to delineate what factors diverge neutrophils from host defense to autoimmune response in RA.