A new checkpoint against ferroptosis

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2020,（1）
• 页码范围: 3-4
• 页数: 2页
• 语种: 英文
• DOI: 10.1038/s41422-019-0258-0

摘要

By taking different approaches,two research groups made the same discovery that a CoQ oxidoreductase (renamed as ferroptosis suppressor protein-1,or FSP1) can inhibit ferroptosis,a form of cell death driven by iron-dependent phospholipid peroxidation.As FSP1 is expressed in various cancers and can halt ferroptosis even in the absence of glutathione peroxidase 4(GPX4),which was previously considered indispensable for ferroptosis surveillance,the potential of FSP1 as a new cancer therapeutic target should be explored.