Synthetic of Some New Fluorine Compounds Bearing 1,2,4-Triazine Moieties and the Related Hetero-Polycyclic Nitrogen Systems as Pharmacological Probes-Overview

• 作者: Dina A. Bakhotmah Fatimah A. Alotaibi
• 来源期刊: 有机化学国际期刊(英文)
• 学科: 化学
• 关键词: Design Synthesis FLUORINATED 1 2 4-Triazino/1 4-Triazinone MEDICINAL Properties
• 年，卷（期）: yjhxgjqkyw_2020,（1）
• 页码范围: 17-38
• 页数: 22页
• 分类号: O62

摘要

This overview summarizes recent advanced literature surveys on the synthesis of fluorine substituted 1,2,4-triazine containing various functional groups and/or the related hetero-polycyclic nitrogen systems have been reported. In addition, physical, chemical, and medicinal properties have been evaluated. The presence of fluorinated atoms often improves these properties with an increasing electronegativity. It, also, enhances the stability of formed carbanion and it improves the hydrophobic effects which have good biological activities.