Radial artery access site complications during cardiac procedures,clinical implications and potential solutions:The role of nitric oxide

• 作者: Emma M Coghill Ian L Megson Russell E Morris Stephen J Leslie Timothy Johnson
• 来源期刊: 世界心脏病学杂志:英文版(电子版)
• 学科: 数学
• 关键词: Radial artery CANNULATION SPASM NITRIC oxide VASODILATION NANOPOROUS material
• 年，卷（期）: 2020,（1）
• 页码范围: 26-34
• 页数: 9页
• 分类号: O17

摘要

Percutaneous coronary intervention for the treatment of coronary artery disease is most commonly performed in the UK through the radial artery,as this is considered to be safer than the femoral approach.However,despite improvements in technology and techniques,complications can occur.The most common complication,arterial spasm,can cause intense pain and,in some cases,procedural failure.The incidence of spasm is dependent on several variables,including operator experience,artery size,and equipment used.An antispasmolytic cocktail can be applied to reduce spasm,which usually includes an exogenous nitric oxide(NO)donor(glyceryl trinitrate).NO is an endogenous local vasodilator and therefore is a potential target for anti-spasm intervention.However,systemic administration can result in unwanted side-effects,such as hypotension.A method that adopts local delivery of NO might be advantageous.This review article describes the mechanisms involved in radial artery spasm,discusses the advantages and disadvantages of current strategies to reduce spasm,and highlight the potential of NO-loaded nanoporous materials for use in this setting.