Type Ⅱ toxin-antitoxin system in bacteria: activation, function, and mode of action

• 作者: Ding-Ding Guo Hu-Yuan Feng Liang Peng Qian Wang Shuo-Wei Quan Si-Ping Zhang Xiao-Quan Yu Yong Wang Yong-Xing He
• 来源期刊: 生物物理学报
• 年，卷（期）: 2020,（2）
• 页码范围: 68-79
• 页数: 12页
• 语种: 中文

摘要

The toxin-antitoxin (TA) system is composed of a stable toxin and an unstable antitoxin that neutralizes the toxin.Being perhaps the most studied among the different TA types,type Ⅱ TA systems are widely distributed and often exist in multiple copies within chromosomes of eubacteria and archaea.Exhibiting diverse molecular activities such as RNases,kinases,and acetyltransferases,type Ⅱ TA systems have been confirmed to be involved in diverse biological processes including plasmid maintenance,phage inhibition,persistence,stress response,and biofilm formation.In this review,we summarize the current state of the research in the type Ⅱ TA field,emphasizing the activation mechanism,structure-function relationship,and biological functions of type Ⅱ TA systems.

作者信息

序号	姓名	单位	发文数	被引次数	H指数	G指数
1	Si-Ping Zhang		1	0	0.0	0.0
2	Qian Wang		1	0	0.0	0.0
3	Shuo-Wei Quan		1	0	0.0	0.0
4	Xiao-Quan Yu		1	0	0.0	0.0
5	Yong Wang		1	0	0.0	0.0
6	Ding-Ding Guo		1	0	0.0	0.0
7	Liang Peng		1	0	0.0	0.0
8	Hu-Yuan Feng		1	0	0.0	0.0
9	Yong-Xing He		1	0	0.0	0.0