Association between hereditary hemochromatosis and hepatocellular carcinoma: a comprehensive review

• 作者: Aparna Jayachandran Darrell H. G. Crawford Kim R. Bridle Ritu Shrestha
• 来源期刊: 肝癌研究（英文版）
• 年，卷（期）: 2020,（3）
• 页码范围: 1-14
• 页数: 14页
• 语种: 英文
• DOI: 10.20517/2394-5079.2019.35

摘要

Hepatocellular carcinoma (HCC) is a significant global health problem with high morbidity and mortality. Its incidence is increasing exponentially worldwide with a close overlap between annual incidence and death rates. Even though significant advances have been made in HCC treatment, fewer than 20％ of patients with HCC are suitable for potentially curative treatment. Hereditary hemochromatosis (HH) is an important genetic risk factor for HCC. HH is an autosomal recessive disorder of iron metabolism, characterised by elevated iron deposition in most organs including the liver, leading to progressive organ dysfunction. HCC is a complication of HH, nearly always occurring in patients with cirrhosis and contributes to increased mortality rates. Identifying the susceptibility of development of HCC in HH patients has gained much traction. This review summarises the current knowledge with regard to the association of HH and HCC in order to encourage further research. In this review, we focus particularly on HFE gene-related HH. Herein, we highlight and discuss emerging clinical research which addresses the prevalence of HCC in HH patients and the coincidence of HH with other risk factors for HCC development. We also focus on the therapeutic tools in the management of HCC associated with HH.