Botulinum Toxin Type A and Its Possible Mechanisms on Wound Healing

• 作者: Bingchen Duan Khushboo Gurung Qian Tan Ye Xu
• 来源期刊: 现代整形外科(英文)
• 学科: 医学
• 关键词: Wound Healing Botulinum Toxin Type-A Hypertrophic Scar KELOID FIBROBLAST MYOFIBROBLASTS Transforming Growth Factor β-1 Collagen METALLOPROTEINASES Connective Tissue Growth Factor
• 年，卷（期）: xdzxwkyw_2020,（3）
• 页码范围: 38-55
• 页数: 18页
• 分类号: R74

摘要

Botulinum toxin type-A (BTX-A), a subtype from known seven types of botulinum neurotoxin (serotype A-G), is produced by a gram-positive bacterium, <i>Clostridium botulinum</i>. The toxin is now widely and efficiently used in treating a plethora of diverse symptoms and conditions. Recent evidence in the literature also shows that BTX-A exhibits a wide range of effects on non-neuronal cells. Its potential has markedly expanded to clinical applications other than the treatment of neurological and muscular conditions that are characterized by neuronal hyperactivity. A number of studies have shown BTX-A to improve the quality of scar outcome and prevent the formation of keloids and HTS. Although the mechanism of action of BTX-A on wound healing is still not clearly understood, lately there has been extensive research to grasp the underlying mechanisms of this multifunctional toxin. BTX-A seems to affect wound healing by a number of mechanisms that include action on tensile forces, inhibition of fibroblasts differentiation, downregulation of TGF-<i><span style="white-space:nowrap;">β</span></i>1 and collagen expression. This review will explore the responses of Botulinum toxin type-A on wound healing and preventing pathological scars like HTS and keloids, and comprehend the overall effect BTX-A has on wound healing.