Design, Synthesis, Chemistry and Biological Evaluation of Some Polyfunctional Heterocyclic Nitrogen Systems—Overview

• 作者: Asmaa L. Alanzy Dina A. Bakhotm Reda M. Abdel-Rahman
• 来源期刊: 有机化学国际期刊(英文)
• 学科: 化学
• 关键词: Pyrazolo[3 4-b]pyridine Simple Heterocyclic Nitrogen Biological Properties Edaravone Drug Synthetic Strategies
• 年，卷（期）: yjhxgjqkyw,（2）
• 页码范围: 39-62
• 页数: 24页
• 分类号: O62

摘要

The synthesis, preparation, chemical reactivities and biological activity of simple heterocyclic and heteropolycyclic nitrogen systems as small units as functional pyrazoles, pyridine and pyrimidine, and the related fused systems are reviewed. Among the various possible routes to the formation, isomeric structures have been cited because of patented reaching advanced phases of clinical trials, from 2000 to 2020.