Three new polyoxygenated bergamotanes from the endophytic fungus Penicillium purpurogenum IMM 003 and their inhibitory activity against pancreatic lipase

• 来源期刊: 中国天然药物
• 学科: 医学
• 年，卷（期）: 2020,（1）
• 页码范围: 75-80
• 页数: 6页
• 分类号: R284.1
• 语种: 英文
• DOI: 10.1016/S1875-5364(20)30007-8

摘要

Purpurolides D-F (1-3),three new polyoxygenated bergamotanes bearing a 6/4/5/5 tetracyclic ring system,were isolated from the endophytic fungus Penicillium purpurogenum IMM 003.Their structures were unambiguously elucidated based on extensive spectroscopic data analyses,13C NMR chemical shifts calculations coupled with the DP4+ probability method,and the calculated and experimental electronic circular dichroism (ECD) spectra.Compounds 1-3 showed significant inhibitory activity against pancreatic lipase (PL).The result highlights that the presence of 3-hydroxylated decanoic acid moiety at C-14 is important for increasing the inhibition potency against PL.