A study of the clinical characteristics in patients with digestive tract cancer related cognitive impairment

• 作者: Mao-Yan Chen Na Yan Qian-Qian Niu Yuan-Hong Zhao Zheng Li Zhi-Li Zhao
• 来源期刊: 心身医学研究
• 学科: 医学
• 关键词: Digestive tract cancer Cognitive impairment/damage Clinical characteristics Risk factors
• 年，卷（期）: 2020,（2）
• 页码范围: 46-53
• 页数: 8页
• 分类号: R73

摘要

Objective:The aims of this study was to explore the clinical characteristics of patients with digestive tract cancer-related cognitive impairment(CRCI),and provide reference for the comprehensive clinical understanding,early prevention and treatment.Methods:164 patients with digestive tract cancer were divided into CRCI group and non-CRCI impairment group based on the Montreal Cognitive Assessment Scale(MOCA)and the Minimal Mental State Scale(MMSE).Baseline features,blood biochemical indexes,anxiety and depression were compared.Statistical analysis were carried out by SPSS software(version 20.0).Results:Among all the patients with CRCI,males were more common.Also,there were statistically differences in marital status,liver metastasis,hypertension,ferritin(FER),high density lipoprotein-cholesterol(HDL-C),low density lipoprotein-cholesterol(LDL-C),NK cells,anxiety and depression(P<0.05).Conclusion:Part of patients with digestive tract cancer have varied degrees of cognitive dysfunction.Marital status,hypertension,immune function,liver metastasis and serum lipid metabolism were the risk factors for patients with digestive tract CRCI.Early identification of CRCI is of great significance to ensure the integrity of treatment,improve the quality of life and prognosis for patients with digestive tract CRCI.