Distinctive magnetic resonance imaging findings of hepatocellular carcinoma after hepatitis C virus eradication with direct-acting antivirals

• 作者: Hiroyuki Nakanishi Jun ltakura Kaoru Tsuchiya Keiya Watakabe Kenta Takaura Leona Osawa Mao Okada Masayuki Kurosaki Mayu Higuchi Namiki lzumi Nobuharu Tamaki Sakura Kirino Shun Kaneko Tadakazu Hisamatsu Takao Shimizu Wan Wang Yuka Takahashi Yutaka Yasui
• 来源期刊: 肝癌研究（英文版）
• 年，卷（期）: 2020,（3）
• 页码范围: 41-49
• 页数: 9页
• 语种: 英文
• DOI: 10.20517/2394-5079.2019.48

摘要

Aim: The aim of the present study was to evaluate the characteristics of the magnetic resonance imaging features of hepatocellular carcinoma (HCC) that developed early after the eradication of hepatitis C virus (HCV) by direct-acting antiviral (DAA) treatment. Methods: This study included 26 patients who achieved sustained viral response with DAA and developed HCC thereafter within one year (DAA-SVR HCC). The radiologic characteristics of these patients were evaluated by contrast-enhanced magnetic resonance imaging, including diffusion-weighted imaging (DWI) and T2-weighted imaging (T2WI). For comparison, 80 HCC patients with positive HCV RNA (HCV-positive HCC) were included. Among 42 patients where tumor biopsy was available, histological grade and radiologic findings were compared. Results: The rates of high intensity on DWI and T2WI were significantly higher in DAA-SVR HCC compared to HCV-positive HCC (DWI: 100％ vs. 67.5％, P < 0.001T2WI: 92.6％ vs. 67.5％, P = 0.01). HCC with high intensity on DWI or T2WI was more likely to have moderately or poorly differentiated HCC compared to well-differentiated HCC (DWI: 69.7％ vs. 30.3％, P = 0.02; T2WI: 66.7％ vs. 27.3％, P = 0.03).Conclusion: High intensity on DWI and hyperintensity on T2WI were distinctive features of HCC that developed within one year after the end of DAA treatment.