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<div style="text-align:justify;"> <span style="font-family:Verdana;">Type 2 diabetes mellitus is a growing health problem, characterized by insulin resistance progressing to beta cell dysfunction and insulin deficiency, most of these patients will need intensification of treatment and initiation of insulin to delay or prevent diabetic complications. Glycemic control is the most important aspect of management, and in reducing morbidity and mortality of the diseases. Control of plasma glucose in patients with diabetes can be assessed by HbA1c, FPG, PPG, but still HbA1c% remains the gold standard for assessment of glycemic control and follow up of diabetic patients. The aim of this study is to assess HbA1c% in patients on oral anti-diabetic drugs, with poor glycemic control before and after adding basal insulin, with titration of the dose of insulin depending on fasting blood sugar. 82 patients with uncontrolled type 2 diabetes (43.9% male, 56.1% female), with HbA1c more than 9%, on two types of oral diabetic medication or more, were started on basal insulin (glargine, lantus) and followed for three to six months. Overall 82 patients with type 2 diabetes mellitus were included in the study. The mean age of the study population was 58.4 years, the mean duration of the disease range was 13.4 years. All patients with HbA1c more than 9%, without organ failure, were included in the study. The mean HbA1c overall had decreased from mean of 11.15% before starting basal insulin to the mean of 8.43% within 3 to 6 month, after initiating basal insulin, this difference was significant at p < 0.001. There was no adverse effect on this medication in any of the study group. The addition of basal insulin to oral anti-diabetic medication in uncontrolled insulin-na<span style="color:#4F4F4F;font-family:"font-size:14px;white-space:normal;background-color:#F7F7F7;">&#239;</span>ve type 2 diabetic patients resulted in significant improvement of glycemic control, with improved HbA1c level, without adverse effects.</span> </div>
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篇名 Initiation of Basal Insulin in Patients with Uncontrolled Type 2 Diabetes Mellitus
来源期刊 内分泌与新陈代谢疾病期刊(英文) 学科 医学
关键词 T2DM—Type 2 Diabetes Mellitus HbA1c—Haemoglobin A1c% FBG—Fasting Blood Glucose PPG—Post Prandial Glucose NPH—Neutral Protamine Hagedorn
年,卷(期) 2020,(6) 所属期刊栏目
研究方向 页码范围 89-93
页数 5页 分类号 R58
字数 语种
DOI
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T2DM—Type
2
Diabetes
Mellitus
HbA1c—Haemoglobin
A1c%
FBG—Fasting
Blood
Glucose
PPG—Post
Prandial
Glucose
NPH—Neutral
Protamine
Hagedorn
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
内分泌与新陈代谢疾病期刊(英文)
月刊
2165-7424
武汉市江夏区汤逊湖北路38号光谷总部空间
出版文献量(篇)
25
总下载数(次)
0
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