Tiaobu Xinshen Recipe（调补心肾方） Improved Mild Cognitive Impairment of Alzheimer's Disease Patients with Xin (Heart) and Shen (Kidney) Deficiency

• 来源期刊: 中国结合医学杂志（英文版）
• 年，卷（期）: 2020,（1）
• 页码范围: 54-58
• 页数: 5页
• 语种: 英文
• DOI: 10.1007/s11655-019-3073-z

摘要

Objective:To observe the intervention effects of Tiaobu Xinshen Recipe(调补心肾方,TXR) on patients with mild cognitive impairment caused by Alzheimer's disease (MCI-AD).Methods:Totally 88 MCI-AD patients with syndrome of Xin (Heart) and Shen (Kidney) deficiency were assigned to the experimental group (47 cases,treated with r'XR) and the control group (41 cases,treated with donepezil hydrochloride) using a random number table.Final recruited qualified patients were 44 cases in the experimental group and 39 cases in the control group.The therapeutic course was 12 weeks.Neuropsychological scales [mini mental state examination (MMSE) and Montreal cognitive assessment (MoCA)],and Chinese medicine (CM) dementia syndromes scales were performed in all patients,and results were compared between groups or intra-group before and after treatment.Results:MMSE and MoCA scores of the two groups were increased after treatment compared with those before treatment (P＜0.05).But there was no statistical difference in MMSE or MOCA scores after treatment between the two groups (P＞0.05).CM dementia syndrome score was significantly decreased after treatment in the experimental group compared with the control group (P＜0.01).Visual spatial and executive function scores and delayed recall scores of the two groups were increased compared with those before treatment (P＜0.01).Conclusion:TXR could effectively improve cognitive impairment of MCI-AD patients with syndrome of Xin and Shen deficiency.