COVID-19 is a devastating outbreak that has developed from December,2019.SARS-CoV-2 is the causative organism of this disease condition.However,as this is a novel virus human race do not know the curative measures of this disease.They don’t know the treatment procedure but only few preventive measures are known to them.In today’s era of nanotechnology,nanoparticles may be used to combat this disease condition.In this publication,a hypothesis is drawn on a prospective therapeutic procedure to combat COVID-19.A nanoconjugate comprising of siRNA and Layered double hydroxide may be used as an intranasal spray to treat this disease condition.Specific siRNA sequence that will target the RNA sequence of the virus will help to resist the replication and infection of the virus.As this nanoconjugate will not have any side effect it may become an optimum therapeutic measure for COVID-19.