γ-catenin alleviates cardiac fibrosis through inhibiting phosphorylation of GSK-3β

• 来源期刊: 生物医学研究杂志（英文版）
• 学科: 医学
• 年，卷（期）: 2020,（1）
• 页码范围: 27-35
• 页数: 9页
• 分类号: R542.2
• 语种: 英文

摘要

Cardiac fibrosis is a common pathological change of many cardiovascular diseases.β-catenin has been shown to promote fibrosis.However,the precise role of its homolog γ-catenin in the process of fibrosis remains largely unclear.In this study,we found that the expression of γ-catenin was significantly decreased in angiotensin Ⅱ (Ang Ⅱ)-induced cardiac fibrosis model,contrary to most reports of β-catenin.Overexpression of γ-catenin in cardiac fibroblasts (CFs) significantly inhibited the expression of α-smooth muscle actin (α-SMA),whereas knocking down the expression of γ-catenin with siRNA promoted the occurrence of cardiac fibrosis.Mechanistically,γ-catenin could bind to GSK-3β to inhibit the phosphorylation of GSK-3β,therefore preventing cardiac fibrosis.Our study shows that γ-catenin is an important protective factor in cardiac fibrosis,which provides a new potential target for the treatment of cardiac fibrosis.