The immune-modulating effects of viable Weissella cibaria JW15 on RAW 264.7 macrophage cells

• 来源期刊: 生物医学研究杂志（英文版）
• 学科: 医学
• 年，卷（期）: 2020,（1）
• 页码范围: 36-43
• 页数: 8页
• 分类号: R392.9
• 语种: 英文

摘要

The objective of this study is to investigate the immune-enhancing ability of viable and heat-killed Weissella cibaria JW15 (JW15) isolated from Kimchi in RAW 264.7 macrophages.The immune effects were evaluated by measuring the production of NO,cytokines,inflammatory enzyme,and activation of NF-κB.Viable JW15 executed higher activity on stimulating the release of TNF-α as well as activating NF-κB compared to that of heatkilled JW15.Additionally,viable and heat-killed JW15 significantly increased the production of NO,IL-6 and TNF-α more than that of Lactobacillus rhamnosus GG (LGG).Furthermore,viable JW15 induced higher production of iNOS compared with that of viable LGG.Collectively,our finding indicates that viable JW15 had similar,if not more,immune-enhancing activities as heat-killed JW15.In addition,viable JW15 had higher immune-enhancing activity than commercial strain LGG.Therefore,viable JW1 5 has the potential to be used as a functional food to improve the host immune response.