Fundamentals about onset and progressive disease character of type 2 diabetes mellitus

• 作者: Rob NM Weijers
• 来源期刊: 世界糖尿病杂志:英文版(电子版)
• 学科: 医学
• 关键词: ATP Free fatty acid Glucose transporter Membrane flexibility METFORMIN Slow-down principle Type 2 diabetes Unsaturation index
• 年，卷（期）: 2020,（5）
• 页码范围: 165-181
• 页数: 17页
• 分类号: R58

摘要

ResearchGate is a world wide web for scientists and researchers to share papers,ask and answer questions,and find collaborators.As one of the more than 15 million members,the author uploads research output and reads and responds to some of the questions raised,which are related to type 2 diabetes.In that way,he noticed a serious gap of knowledge of this disease among medical professionals over recent decades.The main aim of the current study is to remedy this situation through providing a comprehensive review on recent developments in biochemistry and molecular biology,which can be helpful for the scientific understanding of the molecular nature of type 2 diabetes.To fill up the shortcomings in the curricula of medical education,and to familiarize the medical community with a new concept of the onset of type 2 diabetes,items are discussed like:Insulin resistance,glucose effectiveness,insulin sensitivity,cell membranes,membrane flexibility,unsaturation index(UI;number of carboncarbon double bonds per 100 acyl chains of membrane phospholipids),slowdown principle,effects of temperature acclimation on phospholipid membrane composition,free fatty acids,energy transport,onset of type 2 diabetes,metformin,and exercise.Based on the reviewed data,a new model is presented with proposed steps in the development of type 2 diabetes,a disease arising as a result of a hypothetical hereditary anomaly,which causes hyperthermia in and around the mitochondria.Hyperthermia is counterbalanced by the slow-down principle,which lowers the amount of carbon-carbon double bonds of membrane phospholipid acyl chains.The accompanying reduction in the UI lowers membrane flexibility,promotes a redistribution of the lateral pressure in cell membranes,and thereby reduces the glucose transporter protein pore diameter of the transmembrane glucose transport channel of all Class I GLUT proteins.These events will set up a reduction in transmembrane glucose transport.So,a new blood glucose regulation system,effective in type 2 diabetes and its prediabe