The COVID-19 pandemic is a public health emergency.As we write,the world counts more than 10 million positive cases and more than 500 thousand deaths.The difficult conditions faced by healthcare workers helping with the COVID-19 pandemic are leading to severe adverse mental health consequences.The aim of this review is to summarize and analyze the mental health issues that healthcare workers are experiencing during the COVID-19 outbreak.We conduct a systematic literature review to investigate the healthcare workforce’s mental health disorders.About 145 articles were retrieved for the period between January 1,2020 and April 30,2020.After screening,27 articles were selected for full-text examination,13 were included in the review.Of the studies included,69%(9/13)and 61%(8/13)investigated depression and anxiety,respectively,although other mental health disorders such as insomnia,distress,stress,and fear were also assessed.Most of the healthcare workers in the studies reported high levels of stress,anxiety,and severe symptoms of depressions.Caregivers are working under high levels of pressure,in a high-risk environment,and are dealing with many physical and psychological challenges.Appropriate actions and well-timed psychological support to protect medical workers’mental health should be considered.