Prevalence and Determinants of Kidney Markers among Subjects with Hepatitis C Virus Infection

• 作者: Antonin Ndjitoyap Ndam Firmin Ankouane Andoulo François Folefack Kaze Jeanne Ngongang Mathurin Pierre Kowo Michelle Tagny Sartre Murielle Sonia Mehly Ngninzeko Sylvain Raoul Simeni Njonnou Vicky Ama Moor
• 来源期刊: 肾脏病(英文)
• 学科: 医学
• 关键词: Hepatitis C Virus Chronic Kidney Disease PREVALENCE Sub-Saharan Africa
• 年，卷（期）: 2020,（2）
• 页码范围: 85-101
• 页数: 17页
• 分类号: R73

摘要

<strong>Introduction:</strong> Hepatitis C virus (HCV) infection is a worldwide public health problem with multisystemic involvements including kidneys. We assessed the prevalence and determinants of kidney markers among HCV infected subjects. <strong>Methods:</strong> A cross-sectional study was conducted from March to July 2017 in two referral centers in Yaoundé. Sociodemographic, clinical and paraclinical data were collected from patient’s records. Renal involvement was evaluated using estimated glomerular filtration rate (eGFR) by Modification of Diet in Renal Disease’s (MDRD) equation, urine dipstick and albumin/creatinine ratio (ACR). An eGFR < 60 and between 60 - 89 mL/min/1.73 m² was defined as low and reduced respectively. Albuminuria was defined by an ACR > 30 mg/g and divided into A1 (<30 mg/g), A2 (30 - 300 mg/g) and A3 (>300 mg/g). <strong>Results:</strong> We included 65 (41.5% males) HCV infected patients with a mean age of 56.8 ± 10.5 years. HCV infection was diagnosed for more than 5 years in 54 (83.1%) patients. HCV viral load and genotype were available in 40 (61.5%) patients;viral load was high (>5.9 logs/mL) in 20 (50%) of them and genotypes 4 (40%), 1 (32.5%) and 2 (27.5%) were found in this population. The mean eGFR was 112.9 ± 31.9 mL/min/1.73 m² with 14 (21.5%) and 4 (6.2%) patients having reduced and low eGFR respectively. Albuminuria (80%), leukocyturia (24.6%) and hematuria (4.6%) were the observed dipstick abnormalities. Median albuminuria (IQR) was 542.4 (238.7 - 961.5) mg/g, with 7 (11%), 12 (18%) and 46 (71%) patients in A1, A2 and A3 respectively. Reduced/low eGFR and albuminuria were observed in 58 (89.2%) patients while low eGFR and albuminuria were found in 55 (84.6%) patients. Advanced age, female gender, HCV genotype 1 and 4, and albuminuria (all p < 0.03) were associated with eGFR reduction. <strong>Conclusion:</strong> Renal abnormalities are common in HCV infected patients leading by proteinuria and decreased eGFR. Known risk factors of kidney