Regulation of Circadian Genes by the MAPK Pathway: Implications for Rapid Antidepressant Action

• 来源期刊: 神经科学通报（英文版）
• 年，卷（期）: 2020,（1）
• 页码范围: 66-76
• 页数: 11页
• 语种: 英文

摘要

Accumulating evidence suggests that the circadian rhythm plays a critical role in mood regulation,and circadian disturbances are often found in patients with major depressive disorder (MDD).The mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) pathway is involved in mediating entrainment of the circadian system.Furthermore,the MAPK/ ERK signaling pathway has been shown to be involved in the pathogenesis of MDD and the rapid onset of action of antidepressant therapies,both pharmaceutical and non-pharmaceutical.This review provides an overview of the involvement of the MAPK/ERK pathway in modulating the circadian system in the rapid action of antidepressant therapies.This pathway holds much promise for the development of novel,rapid-onset-of-action therapeutics for MDD.