Application and challenges of RNA interference in reversing multidrug resistance of tumor cells

• 作者: Bao-Wei Cui Jing-Cheng Song Shu-Di Yang Yue Gao
• 来源期刊: 肿瘤微环境研究
• 学科: 医学
• 关键词: RNA interference Small interfering RNA TUMOR Multidrug resistance
• 年，卷（期）: 2020,（4）
• 页码范围: 117-123
• 页数: 7页
• 分类号: R73

摘要

RNA interference,widely regarded as a key mechanism for cells to regulate gene expression,is a natural gene silencing phenomenon.It can be used as the gene knockdown to reverse the multidrug resistance of tumor cells and has been applied in the field of biomedicine,exhibiting huge potential in drug target identification,optimization of drug targets,multidrug resistance,etc.This paper first introduces the mechanism of RNA interference and the formation mechanism of multidrug resistance of tumor cells,on the basis of which it reviews the application and challenges of RNA interference technology in reversing multidrug resistance.Additionally,the development of the siRNA delivery system is illustrated.