Ameliorating Effects of Delphinol®, Anthocyanin Standardized Maqui Berry Extract, on Skin Brightness and Redness in Japanese Females: A Randomized Double-Blind Placebo-Controlled Pilot Study

• 作者: Hiroshi Shimoda Kenchi Miyasaka Norihito Shimizu Wakana Yamada
• 来源期刊: 化妆品、皮肤病及应用期刊(英文)
• 学科: 文学
• 关键词: Maqui Berry Delphinidin Glucoside Anthocyanins SKIN BRIGHTNESS Saturation Redness Collagen Score
• 年，卷（期）: 2020,（4）
• 页码范围: 149-162
• 页数: 14页
• 分类号: J53

摘要

Maqui berries are wildly grown or cultivated in the Patagonian region in Chile. The berries contain large amounts of anthocyanins, especially delphinidin glycosides, which are strong anti-oxidants. We previously reported that standardized maqui berry extract, which contained lots of anthocyanins, has ameliorative effects against dry eyes and visible light-induced photoreceptor cell damage. However, the influence of maqui berry extract on the human skin has not been evaluated even though many skin troubles are related to active oxygen species. Therefore, we conducted a randomized double-blind placebo-controlled pilot study with Delphinol<span style="font-family:Verdana, Helvetica, Arial;white-space:normal;background-color:#FFFFFF;"><span style="font-family:Verdana, Helvetica, Arial;white-space:normal;background-color:#FFFFFF;">&#174;</span></span>, a maqui berry extract standardized for anthocyanins, especially delphinidins and cyanidins, in healthy Japanese female subjects. Capsules containing Delphinol<span style="font-family:Verdana, Helvetica, Arial;white-space:normal;background-color:#FFFFFF;"><span style="font-family:Verdana, Helvetica, Arial;white-space:normal;background-color:#FFFFFF;"><span style="font-family:Verdana, Helvetica, Arial;white-space:normal;background-color:#FFFFFF;">&#174;</span></span></span> (60 mg) or placebo were orally administered to subjects aged 27 to 57 years old for eight weeks. Skin conditions [pigmentation, redness, skin tone, wrinkles, texture, oil content, water content, trans epidermal water loss (TEWL), collagen score, dermal thickness, and elasticity] were measured before and after intervention. In the Delphinol<span style="font-family:Verdana, Helvetica, Arial;white-space:normal;background-color:#FFFFFF;"><span style="font-family:Verdana, Helvetica, Arial;white-space:normal;background-color:#FFFFFF;"><span style="font-family:Verdana, Helvetica, Arial;white-space:normal;background-color:#FFFFFF;">&#174;</span></span></span> group, the saturation significantly increased after