Cystic fibrosis-related diabetes:The unmet need

• 作者: Fatimah Bello Leonardo Pozo Salim Surani Yamely Mendez
• 来源期刊: 世界糖尿病杂志:英文版(电子版)
• 学科: 工学
• 关键词: Cystic fibrosis Cystic fibrosis-related diabetes Cystic fibrosis transmembrane conductance regulator Gastric inhibitory polypeptide Glucagon-like peptide 1 Glucagon-like peptide-1 receptor agonist Dipeptidyl peptidase 4 inhibitors
• 年，卷（期）: 2020,（6）
• 页码范围: 213-217
• 页数: 5页
• 分类号: TV6

摘要

Cystic fibrosis(CF)is a common autosomal recessive disease.Life expectancy of patients with CF continues to improve mainly driven by the evolving therapies for CF-related organ dysfunction.The prevalence of CF-related diabetes(CFRD)increases exponentially as patients’age.Clinical care guidelines for CFRD from 2010,recommend insulin as the mainstay of treatment.Many patients with CFRD may not require exogenous insulin due to the heterogeneity of this clinical entity.Maintenance of euglycemia by enhancing endogenous insulin production,secretion and degradation with novel pharmacological therapies like glucagonlike peptide-1 agonist is an option that remains to be fully explored.As such,the scope of this article will focus on our perspective of glucagon-like peptide-1 receptor agonist in the context of CFRD.Other potential options such as sodiumglucose cotransporter-2 and dipeptidyl peptidase 4 inhibitors and their impact on this patient population is limited and further studies are required.