Role of novel biomarkers in kidney transplantation

• 作者: Arjang Djamali Didier Mandelbrot Fahad Aziz Kurtis J Swanson Maha Mohamed Neetika Garg Sandesh Parajuli
• 来源期刊: 世界移植杂志
• 学科: 医学
• 关键词: Biomarkers Kidney Transplantation REJECTION INFECTION MORTALITY Graft survival
• 年，卷（期）: 2020,（9）
• 页码范围: 230-255
• 页数: 26页
• 分类号: R69

摘要

Clinical application of biomarkers is an integral component of transplant care.Clinicians and scientists alike are in search of better biomarkers than the current serologic(serum creatinine,donor-specific antibodies),urine-derived(urinalysis,urine protein),and histologic ones we now use.The science behind recent biomarker discovery spans across multiple molecular biologic disciplines,including transcriptomics,proteomics,and metabolomics.Innovative methodology and integration of basic and clinical approaches have allowed researchers to unearth molecular phenomena preceding clinical disease.Biomarkers can be classified in several ways.In this review,we have classified them via their origin and outcome:Primarily immunologic,i.e.,representative of immune regulation and dysfunction and non-immunologic,pertaining to delayed graft function,cardiovascular events/mortality,infection,malignancy,posttransplant diabetes,graft,and patient survival.Novel biomarker uses to guide the diagnosis and management of transplant-related outcomes is a promising area of research.However,the use of biomarkers to predict outcomes after kidney transplantation is not well studied.In this review,we summarize the recent studies illustrating biomarker use and transplant outcomes.