With the development of aviation industry, civil aviation has become an indispensable part. Our team will take all the structural dimensions, loads and material parameters in the wing beam structure as the specific values determined during the structural design to conduct deflection analysis on the wing beam structure of A380 passenger plane. According to the deflection and parameters analyzed, the stress distribution and maximum stress position on the wing beam can be known. Through the analysis of the wing parameters, the finite element analysis of the wing beam, the mesh sensitivity analysis, and the analysis of the wing tip deflection, the relevant safety factors of the aircraft are obtained. The results show that the wing of airbus A380 is more reliable and safer through the calculation of deflection, stress and safety factor.