Caryophyllene-type sesquiterpenoids and α-furanones from the plant endophytic fungus Pestalotiopsis theae

• 来源期刊: 中国天然药物
• 学科: 医学
• 年，卷（期）: 2020,（4）
• 页码范围: 261-267
• 页数: 7页
• 分类号: R284
• 语种: 英文
• DOI: 10.1016/S1875-5364(20)30032-7

摘要

Two new caryophyllene-type sesquiterpenoids,pestathenols A (1) and B (2) and one new α-furanone,pestatheranone A (6),along with five known compounds (3-5,7 and 8) have been isolated from the crude extract of the plant endophytic fungus Pestalotiopsis theae.Their structures were unambiguously established by extensive spectroscopic analyses.The absolute configuration of the 5,6-diol moiety in 1 was assigned using Snatzke's method.Compounds 1 and 2 showed weak cytotoxicity against HeLa cell line.