Enhanced store-operated calcium entry in platelets is associated with acute coronary syndrome
基本信息来源于合作网站,原文需代理用户跳转至来源网站获取
摘要:
Acute coronary syndrome (ACS) is associated with sudden,reduced blood flow to the heart and usually correlated with coronary thrombosis [1].Therefore,platelets play an important part in the pathogenesis and complications of ACS.Platelet activation is a complex event involving activation of intracellular signaling cascades,such as calcium signaling,which leads to platelet activation,secretion and aggregation.Platelets are highly specialized secretory cells that have a well characterized pattern of cell activation and intracellular signaling.Platelet activation causes increased cytosolic Ca2+ concentration,which could be limited by accelerating sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA)activity [2].SERCA activity can be regulated by Ca2+/calmodulin-dependent protein kinase Ⅱ (CaMKII) [3].Furthermore,it has been shown that CaMKII is increased in activated platelets,indicating that cytosolic Ca2+ concentration is crucial to induce platelet activation [4].