Background:To understand the psychological reaction and coping strategies of infectious diseases among nursing students.Methods:A convenience sampling method was used to select 455 nursing students in the school,and a questionnaire survey was conducted on the general data table and the psychological reaction and coping strategy scale of infectious diseases of college students and coronavirus disease 2019(COVID-19)was used as an example of the infectious diseases.Results:the psychological reaction of nursing students was related to gender(P=0.006),age(P=0.001),education level(P=0.019),professional category of senior high school(P=0.014),whether they were student cadres(P<0.001)and whether there were immediate relatives engaged in medical and health related work(P=0.022).Different education level(P=0.017),different age(P=0.041),different residence(P=0.003),high school professional category(P=0.008)and whether there are immediate relatives engaged in medical and health related work(P=0.021)are related to their coping strategies.Conclusion:Nursing students with different demographic data have different psychological reactions and coping strategies.In the future research on the infectious diseases related to nursing students,it is suggested to focus on the female,the younger,the less educated,the liberal arts students and the nursing students who have no immediate family members engaged in medical and health related work,so as to promote the physical and mental health development of the nursing students in school.