CO as a therapeutic agent: discovery and delivery forms

• 来源期刊: 中国天然药物
• 学科: 医学
• 年，卷（期）: 2020,（4）
• 页码范围: 284-295
• 页数: 12页
• 分类号: R284
• 语种: 英文
• DOI: 10.1016/S1875-5364(20)30036-4

摘要

Carbon monoxide (CO) as one of the three important endogenously produced signaling molecules,termed as "gasotransmitter," has emerged as a promising therapeutic agent for treating various inflammation and cellular-stress related diseases.In this review,we discussed CO's evolution from a well-recognized toxic gas to a signaling molecule,and the effort to develop different approaches to deliver it for therapeutic application.We also summarize recently reported chemistry towards different CO delivery forms.