Epidemiological, Clinical and Biological Characteristics of Patients with Chronic Hepatitis B Infection Followed-Up at the University Hospital of Conakry, Guinea

• 作者: Alpha Amadou Sank Dillo Alpha Mamadou Diallo Amadou Diouldé Doumbouya Djenabou Diallo Kadiatou Diallo Mamadou Mansour Diallo Ousmane Sow Thierno Amadou Wann Youssouf Baldé
• 来源期刊: 肠胃病学期刊(英文)
• 学科: 医学
• 关键词: Viral Hepatitis B EPIDEMIOLOGY CLINICAL BIOLOGY
• 年，卷（期）: 2020,（10）
• 页码范围: 256-265
• 页数: 10页
• 分类号: R51

摘要

<b><span style="font-family:Verdana;">Introduction:</span></b><span style="font-family:""><span style="font-family:Verdana;"> Very little information is available in Guinea on chronic hepatitis B infections. The objective of this study was to describe the epidemiological, clinical and biological features of patients who are chronic carriers of the hepatitis B virus. </span><b><span style="font-family:Verdana;">Patients and Methods:</span></b><span style="font-family:Verdana;"> This is a retrospective study carried out from January 2017 to May 2020, based on the medical records of patients seen via consultation or hospitalized with a record of positive HBs antigen for more than 6 months. Clinical and paraclinical data were collected and analyzed. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> Seven hundred and sixteen patients with a mean age of 35.6 ± 12.2 (sex ratio 2.05)</span></span><span style="font-family:Verdana;">,</span><span style="font-family:Verdana;"> were included. The HBs antigen was discovered incidentally in 36% of cases (n = 258). A history of dental care and surgical procedures was found in 46.3% (n = 290) and 21.1% (n = 138) of cases, respectively. The median value of ALAT enzymes was 34 (21 - 47) IU/L. HBeAg was positive in 20.8% (n = 55/265) of cases. The median B viral load was 458.5 (87</span><span style="font-family:""> </span><span style="font-family:Verdana;">-</span><span style="font-family:""> </span><span style="font-family:Verdana;">3827) IU/ml and 29% (n = 94) of patients had a viral load over 2000 IU/ml. Anti-HCV antibody was present in 10.4 % of cases (n = 39/374). HIV serology was positive in 2.7% (n = 8/298). A total of 19.4% (n = 139) of the patients had cirrhosis and 4.5% (n = 32) had hepatocellular carcinoma.</span><span style="font-family:""> </span><b><span style="font-family:Verdana;">Conclusion:</span></b><span style="font-family:""> </span><span style="font-family:Verdana;">The discovery of chronic HBs antigen was mos