Torsional Dynamics and 2D Speckle Tracking in Heart Failure with Reduced Ejection Fraction on Patients Taking Sacubitril/Valsartan and Naive

• 作者: Ehab Kamal EL Melegy Mena Emad Shafek Walaa Faried Wassam EL Din EL Shafey
• 来源期刊: 心血管病(英文)
• 学科: 医学
• 关键词: HFrEF ARNI SPECKLE Tracking Untwisting Rate and Untwisting ONSET
• 年，卷（期）: 2020,（5）
• 页码范围: 294-304
• 页数: 11页
• 分类号: R73

摘要

This study aims to evaluate the torsional dynamics and 2D speckle tracking in heart failure with reduced ejection fraction on patients taking angiotensin receptor neprilysin inhibitors (ARNI) and none.?ARNI has been shown to be superior to enalapril in?the?long term reducing the mortality and hospitalization of heart failure (HF). However short-term effects on diastolic function remain unclear. We sought to evaluate 6 months' effects of ARNI on left ventricular (LV) diastolic parameters determined by speckle tracking and tissue Doppler imaging. This study was carried out in Menoufia University Hospitals including 60 patients of HFrEF during the period from August 2019 to January 2020. (50%) of patients were?treated with traditional treatment of heart failure and the remaining were?treated with ARNI. Data were collected including history and clinical examination. ECG and speckle tracking and tissue Doppler imaging were?done to evaluate the diastolic function. Our results showed no significant difference between the two groups at baseline. There was?a?significant improvement?in?the LV diastolic function parameters. Untwisting?time and untwisting?onset showed the highly significant parameters of improvement. This study concluded that ARNI showed short term improvement of diastolic function of the left ventricle that could be detected by STE.