<strong>Background:</strong><span style="font-family:;" "=""><span style="font-family:Verdana;"> First described by Handmann in 1929, the “Morning Glory Syndrome” is a rare congenital anomaly of the optic papilla whose notable ophthalmoscopic sign is papillary excavation associated with other ocular and/or non-ocular anomalies. </span><b><span style="font-family:Verdana;">Purpose:</span></b><span style="font-family:Verdana;"> The main purpose of this study is to report 2 cases of this rare congenital papilla anomaly in 2 young Malian adults diagnosed in the IOTA-University Hospital respectively in January and May 2020. </span><b><span style="font-family:Verdana;">Materials and methods:</span></b><span style="font-family:Verdana;"> In our study, we have included two cases of </span><span style="font-family:Verdana;">male</span><span style="font-family:Verdana;"> gender. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> In the 1</span><sup><span style="font-family:Verdana;">st</span></sup><span style="font-family:Verdana;"> case the defect concerned both papillae. It </span><span style="font-family:Verdana;">is also associated with other ocular malformations (bilateral macular reshaping</span><span style="font-family:Verdana;"> and unilateral cataract), without associated cerebral defects. In the 2</span><sup><span style="font-family:Verdana;">nd</span></sup><span style="font-family:Verdana;"> case, only one papilla was affected by the malformation and there was an absence of associated malformations of other ocular and cerebral structures. </span><b><span style="font-family:Verdana;">Discussion:</span></b><span style="font-family:Verdana;"> The Morning Glory Syndrome is part of the group of congenital defects of the optic nerve. It is often referred to as ectasia coloboma of the optical papilla or bindweed flower-like optical papilla because of its similarity to the tropical flower known as “bindweed”. Its exact pathogenesis remains unknown, but it is linke