Predictable site-selective radical fluorination of tertiary ethers

• 来源期刊: 中国科学:化学（英文版）
• 年，卷（期）: 2020,（2）
• 页码范围: 187-191
• 页数: 5页
• 语种: 英文

摘要

In this communication,we disclose the first example of metal-free and site-selective radical fluorination of readily available tertiary alkyl ethers,enabled by synergistic photocatalysis and organocatalysis.This catalytic combination allows for exclusive fluorination of tertiary C-O bonds under mild conditions even in the presence of competing reaction sites.The excellent functional group tolerance affords valuable access to sterically hindered alkyl fluorides through late-stage modification of complex molecules.The successful use of tertiary alkyl ethers in radical fluorination enhances the structural diversity of aliphatic fluorides that can be derived from naturally abundant alcohols.