A Cu/Cinchona P,N-ligand system enabled general asymmetric C(sp3)-C(sp) coupling

• 作者: Chao-Jun Li Xianwei Li
• 来源期刊: 中国科学:化学（英文版）
• 年，卷（期）: 2020,（6）
• 页码范围: 751-752
• 页数: 2页
• 语种: 英文

摘要

Due to the special structural feature and versatile reactivity towards various types of transformations, alkynes have inspired continuous research interest for their generation, incorporation and application in organic synthesis, chemical biology and material science [1].Notably, since its invention in 1975, the Sonogashira reaction, which efficiently couples aryl halides with aryl or vinyl terminal alkynes via Pd(0)/Cu (Ⅰ) synergistic catalysis, has proven to be one of the most reliable methodologies for alkyne synthesis [2].