Mechanical suppression of breast cancer cell invasion and paracrine signaling to osteoclasts requires nucleo-cytoskeletal connectivity

• 作者: Xin Yi Laura E.Wright Gabriel M.Pagnotti Gunes Uzer Katherine M.Powell Joseph M.Wallace Uma Sankar Clinton T.Rubin Khalid Mohammad Theresa A.Guise William R.Thompson
• 来源期刊: 骨研究（英文版）
• 年，卷（期）: 2020,（4）
• 所属期刊栏目: ORIGINAL ARTICLES
• 页码范围: 393-405
• 页数: 13页
• 语种: 英文

摘要

INTRODUCTION Physical activity has beneficial consequences on nearly every organ system. In addition to the positive effects of exercise on cardiovascular1 and musculoskeletal health,2 regular physical activity is associated with a reduced risk of colon, endometrial, and breast cancers.3–4 Women who exercise, at a moderate intensity for 3–4 h per week, have a 30％–40％ reduced risk of breast cancer, compared to sedentary women.5 In addition, physical activity is associated with decreased cancer mortality6 and reduced tumor size in mice that ran long distances.