Efficient Knoevenagel condensation catalyzed by imidazole-based halogenfree deep eutectic solvent at room temperature

• 作者: Bingjian Zhang Hao Qin Hongye Cheng Lifang Chen Qian Zeng Yishan Zhou Zhiwen Qi
• 来源期刊: 绿色能源与环境:英文版
• 学科: 化学
• 关键词: Halogen-free DES Knoevenagel condensation Room temperature Recyclable catalyst Solvent-free condition
• 年，卷（期）: 2020,（2）
• 页码范围: 124-129
• 页数: 6页
• 分类号: O62

摘要

For the first time,we employed the halogen-free deep eutectic solvent(DES)into the Knoevenagel condensation between aromatic aldehydes and active methylene compounds at room temperature.The DESs[3Im:PTSA]and[4Im:PTSA]were prepared by imidazole(Im)and p-tol-uenesulfonic acid(PTSA),which were experimentally screened from a series of organic acids with imidazole.a,b-Unsaturated carbonyl compounds were obtained in good to excellent yields under solvent-free conditions with fast reaction rate.These two DESs can be reused for multiple times with no loss of catalytic activity.