Mathematical modeling of cancer treatment with radiation and PD-L1 inhibitor

• 来源期刊: 中国科学：数学（英文版）
• 年，卷（期）: 2020,（3）
• 页码范围: 465-484
• 页数: 20页
• 语种: 英文

摘要

Radiation therapy is a longstanding cancer treatment.More recently,it has been demonstrated that radiation therapy (RT) elicits anti-cancer immune response.For this reason,there is a growing interest in combining RT with immunotherapy,specifically with checkpoint inhibitors such as anti-CTLA-4 and anti-PD-L1.In the present paper,we develop a mathematical model of combination therapy with RT and anti-PD-L1.The model is used to compare different schedules in clinical trials.Simulations of the model show that applying both RT and anti-PD-L1 at the same week has more benefits than applying them in separate adjacent weeks.Furthermore,applying anti-PD-L1 before RT has more benefits than applying RT before anti-PD-L1.