Biological Disruptive Therapies as Counter Measures for Unpredictable Biological Insults, a Case for Successful Treatment of COVID-19

• 作者: Mohammad Nezami Vicky Yamamoto
• 来源期刊: 传染病进展(英文)
• 学科: 医学
• 关键词: COVID-19 Acute Respiratory Distress Syndrome(ARDS) Phosphoinositol 3 Kinase (Pi3K) QUERCETIN
• 年，卷（期）: 2020,（S1）
• 页码范围: 175-183
• 页数: 9页
• 分类号: R73

摘要

Treatment of patients with severe COVID-19, is challenging specifically when a patient carries high risk of mortality, such as old age, immune suppression or cancer. Also a patient who manifests the disease with severe symptoms, such as hypoxia, requiring supplemental oxygenation, or artificial ventilation has a poor prognosis. Here we review the scientific rationale used to design a very promising therapy based on existing literature, but in significantly different method and protocols, used to treat cases of severe COVID-19, and we conclude that although the effort on drug development has been enormous, but as of today, we do not have a therapy with specific characteristics as this protocol, to be used safely in human and yet potentially meet the expectations we would have for a so called “effective therapy”. Further clinical trials are needed to support this hypothesis and generate further hypothesis to prove the concept in larger cohort of patients.