High intratumoral expression of elF4A1 promotes epithelial-to-mesenchymal transition and predicts unfavorable prognosis in gastric cancer

• 来源期刊: 生物化学与生物物理学报（英文版）
• 关键词: elF4A1 gastric cancer epithelial-to-mesenchymal transition prognostic factor
• 年，卷（期）: 2020,（3）
• 页码范围: 310-319
• 页数: 10页
• 语种: 英文
• DOI: 10.1093/abbs/gmz168

摘要

Gastric cancer is an important health problem,being the fifth most common cancer and the third leading cause of cancer-related death worldwide.Aberrant protein translation contributes to the oncogenesis and development of cancers,and upregulation of translation initiation factor elF4A1 has been observed in several kinds of malignancies.However,the role of elF4A1 in gastric cancer progression remains unclear.In this study,we found that the expression of elF4A1,a component of translation initiation complex,was increased in gastric cancer.High expression of elF4A1 was positively associated with poor tumor differentiation,late T stage,lymph node metastasis,advanced TNM stage,and poor prognosis in patients with gastric cancer.Overexpression of elF4A1 promoted the migration and invasion of gastric cancer cells in vitro and enhanced tumor metastasis in nude mice model.Mechanism studies revealed that elF4A1 induced epithelial-to-mesenchymal transition (EMT) of gastric cancer cells through driving the translation of SNAI1 mRNA.Together,these findings indicate that elF4A1 promotes EMT and metastasis of gastric cancer and suggest that elF4A1 is a potential target for the adjuvant therapy for gastric cancer patients.