A novel small-molecule near-infrared Ⅱ fluorescence probe for orthotopic osteosarcoma imaging

• 作者: Deliang Chen Hui Zhou Jiacheng Lin Qianqian Li Qihang Ding Xianli Meng Xiaodong Zeng Xuechuan Hong Yang Li Yuling Xiao Zixin Deng Ziyang Chen
• 来源期刊: 中国科学:化学（英文版）
• 年，卷（期）: 2020,（6）
• 页码范围: 766-770
• 页数: 5页
• 语种: 英文

摘要

Osteosarcoma is the most common primary malignant tumor of bone,particularly among children and adolescents.Advances in imaging,surgical techniques,and implants have dramatically reduced the need for amputation in the past three decades.Recently,in vivo fluorescence imaging in the second near-infrared window (NIR-Ⅱ,1,000-1,700 nm) shows impressive advantages of deeper tissue penetration and higher spatial resolution,which makes it a promising tool for the early diagnosis and post-operative observation of Osteosarcoma.To the best of our knowledge,this paper is the first time to develop a novel NIR-Ⅱ fluorescence probe conjugated with an osteosarcoma targeted oligopeptide for molecular tumor imaging in a xenograft orthotopic osteosarcoma mouse model.