In situ apolipoprotein E-enriched corona guides dihydroartemisinin-decorating nanoparticles towards LDLr-mediated tumor-homing chemotherapy

• 作者: Biao Cai Cong Luo Dan Li Huicong Zhang JianWang Jiaojiao Zhu Jin Sun LiLi Yin Lu Zhong Mei Zhou Shuangying Gui Shunzhe Zheng Wei Li Yongjun Wang Yongqi Wang Zhenbao Li
• 来源期刊: 亚洲药物制剂科学(英文)
• 学科: 医学
• 关键词: In situ ApoE-enriched corona DHA decoration Nanoparticulate drug delivery system LDLr-mediated tumor-homing CHEMOTHERAPY
• 年，卷（期）: 2020,（4）
• 页码范围: 482-491
• 页数: 10页
• 分类号: R73

摘要

The therapeutic efficiency of active targeting nanoparticulate drug delivery systems(nano-DDS)is highly compromised by the plasma proteins adsorption on nanoparticles(NPs)surface,which significantly hinders cell membrane receptors to recognize the designed ligands,and provokes the off-target toxicity and rapid clearance of NPs in vivo.Herein,we report a novel dihydroartemisinin(DHA)-decorating nano-DDS that in situ specifically recruits endogenous apolipoprotein E(apoE)on the NPs surface.The apoE-anchored corona is able to prolong PLGA-PEG2000-DHA(PPD)NPs circulation capability in blood,facilitate NPs accumulating in tumor cells by the passive enhanced permeability and retention(EPR)effect and low-density lipoprotein receptor(LDLr)-mediated target transport,and ultimately improve the in vivo antitumor activity.Our findings demonstrate that the strategy of in situ regulated apoE-enriched corona ensures NPs an efficient LDLr-mediated tumor-homing chemotherapy.