Recent advances in dopaminergic strategies for the treatment of Parkinson's disease

• 来源期刊: 中国药理学报（英文版）
• 关键词: Parkinson's disease dopamine D1 receptor D2 receptor allosteric modulator neuroprotection multitarget drug discovery and development neurodegenerative diseases
• 年，卷（期）: 2020,（4）
• 页码范围: 471-482
• 页数: 12页
• 语种: 英文

摘要

Parkinson's disease (PD) is the second most common progressive neurodegenerative disease worldwide.However,there is no available therapy reversing the neurodegenerative process of PD.Based on the loss of dopamine or dopaminergic dysfunction in PD patients,most of the current therapies focus on symptomatic relief to improve patient quality of life.As dopamine replacement treatment remains the most effective symptomatic pharmacotherapy for PD,herein we provide an overview of the current pharmacotherapies,summarize the clinical development status of novel dopaminergic agents,and highlight the challenge and opportunity of emerging preclinical dopaminergic approaches aimed at managing the features and progression of PD.