Forks in the road to the first hematopoietic stem cells

• 作者: Elizabeth D.Howell Nancy A.Speck
• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2020,（6）
• 页码范围: 457-458
• 页数: 2页
• 语种: 英文

摘要

Hou et al.examine the origin of hemogenic endothelial cells (HECs) by single-cell RNA sequencing.They show that arterial endothelial cells and HECs are derived from a common early arterial endothelial cell precursor, and that some HECs and their immediate progeny retain the capacity to generate both endothelial and hematopoietic cells longer than previously thought. The first hematopoietic stem cells (HSCs) with long-term repopulating potential in mammalian embryos differentiate at mid-gestation from hemogenic endothelial cells (HECs) located primarily in the dorsal aorta through an endothelial-to-hematopoietic transition (EHT).1,2 The precise molecular identity and source of the endothelial cell (EC) precursors of HECs is not fully understood, although it is widely believed that HECs originate from arterial ECs.