With the support by the National Natural Science Foundation of China,the research team led by Dr.Zhou Qing (周青) at the Life Sciences Institute,Zhejiang University,identified an early-onset autoinflammatory disorder caused by heterozygous mutations in the gene encoding RIPK1,an important regulator of apoptosis,necroptosis and innate immune signalling pathways,which was published in Nature (2020,577:109-114).