3-Methylcholanthrene alters the hepatic immune response in mice

• 作者: Wenyu Miao Yuanxiang Jin Zhengwei Fu
• 来源期刊: 生物化学与生物物理学报（英文版）
• 年，卷（期）: 2020,（5）
• 页码范围: 570-572
• 页数: 3页
• 语种: 英文
• DOI: 10.1093/abbs/gmaa020

摘要

Polycyclic aromatic hydrocarbons (PAHs) are a broad class of semivolatile organic compounds considered to be dangerous environmental pollutants.They are ubiquitously found in air, water, and soil pollution, increasing the risk of potential human and wildlife exposure [1].Their role as the exogenous ligands of the aryl hydrocarbon receptor (AHR) allows them to bind competitively to AHR and recognize its cognate DNA binding site, the xenobiotic response elements (XREs).XREs are located in the regulatory regions of AHRresponsive genes, and their binding leads to the activation of the transcription of the downstream target genes, including cyp1a1 and cyp1b1 [2-6].