Hepatic and reproductive toxicity of sub-chronic exposure to dichlorvos and lead acetate on male Wistar rats

• 作者: Adeniran Oluwadamilare Akinola Adeoye Oyewole Idris Ikponmwosa Aikpitanyi Oore-oluwapo Ololade Daramola Wahab Adekunle Oyeyemi
• 来源期刊: 亚太生殖杂志（英文版）
• 年，卷（期）: 2020,（6）
• 所属期刊栏目: Original Articles
• 页码范围: 283-290
• 页数: 8页
• 语种: 英文
• DOI: 10.4103/2305-0500.298776

摘要

Objective: To investigate the hepatic and reproductive toxicity of dichlorvos and lead acetate on male Wistar rats. Methods: Fifteen adult male Wistar rats (170-190 g) were randomly divided into three groups, with 5 rats in each group. Group 1 received 0.5 mL distilled water orally and served as the control group, while groups 2 and 3 were orally treated with 2 mg/kg body weight (b.w.) dichlorvos and 10 mg/kg b.w. lead acetate, respectively, for 55 days. Epididymal sperm, serum follicle stimulating hormone (FSH), luteinizing hormone (LH), testosterone concentrations, testicular 17β-hydroxysteroid dehydrogenase activity (17β-HSD), androgen receptor expression, aspartate aminotransferase (AST), alanine aminotransferase (ALT), testicular oxidant and antioxidant enzymes were evaluated with standard methods. Results: Sperm count, motility, morphology, FSH, LH, testosterone levels, 17β-HSD, androgen receptor expression, and catalase activity were significantly reduced in the dichlorvos and lead acetate treated groups as compared with the control group (P<0.05). The liver AST, ALT activities and malondialdehyde concentration were significantly increased in the dichlorvos and lead acetate treated groups as compared with the control group (P<0.05). Conclusions: The reproductive and hepatic toxicity activities of dichlorvos and lead acetate in male Wistar rats are similar.