Targeting autophagy-related protein kinases for potential therapeutic purpose

• 来源期刊: 药学学报（英文版）
• 关键词: Autophagy Protein kinases Autophagy-related kinase Phosphorylation Small-molecule kinase inhibitors/activators Human disease therapy
• 年，卷（期）: 2020,（4）
• 页码范围: 569-581
• 页数: 13页
• 语种: 英文

摘要

Autophagy,defined as a scavenging process of protein aggregates and damaged organelles mediated by lysosomes,plays a significant role in the quality control of macromolecules and organelles.Since protein kinases are integral to the autophagy process,it is critically important to understand the role of kinases in autophagic regulation.At present,intervention of autophagic processes by small-molecule modulators targeting specific kinases has becoming a reasonable and prevalent strategy for treating several varieties of human disease,especially cancer.In this review,we describe the role of some autophagy-related kinase targets and kinase-mediated phosphorylation mechanisms in autophagy regulation.We also summarize the small-molecule kinase inhibitors/activators of these targets,high-lighting the opportunities of these new therapeutic agents.