New meroterpenoids and C-methylated flavonoid isolated from Baeckea frutescens

• 来源期刊: 中国天然药物
• 学科: 医学
• 年，卷（期）: 2020,（5）
• 页码范围: 379-384
• 页数: 6页
• 分类号: R284
• 语种: 英文
• DOI: 10.1016/S1875-5364(20)30044-3

摘要

Phytochemical investigation of the aerial parts of Baeckea frutescens resulted in the isolation of three new mono-or sesquiterpene-based meroterpenoids,frutescones S-U (1-3),and one pair of new (±)-5,7-dihydroxy-8-isobutyryl-6-methyldihydroflavonol (4).Their structures and absolute configurations were established by HR-ESI-MS,1D and 2D NMR,and quantum chemical ECD calculation.Compound 1 exhibited inhibitory effect on NO production in LPS-activated RAW 264.7 macrophages with an IC50 value being 0.81 μmol·L-1.